I'd like to start this because there is alot of foreshadowing in ME2 and I'd like to see what you guys think. Try to back up your points though at least.
I think Thane is going to die sometime in ME3 but there will be a large twist before the end. (this one I think is pretty sound)
I also think that we will have to fight a Krogan Reaper at some point because of all the Krogan Okeer said he gave to the collectors. (excited for this one)
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Fyi, this is clearly a discussion and not a question. All "answers" will be speculative. Next time you make a discussion uncheck the box that says this is a question.