Neither really. Homer is the only Simpson I enjoy. The rest of the game family is just annoying, especially those 2 monster children. Family Guy goes a step further with having no redeemable family members. Stewie and Brian were the last hold outs but they screwed them up too.
American Dad is more to my liking. I've actually avoided Bob's Burgers due to the art style but have seen 2 episodes recently and rather liked it. The family seems solid all around (no one annoys me but that's 2 episodes).
Shows with families though kind of leave me hating a lot of them. For instance, I enjoy King of the Hill but **bleep** do I loathe the Hills. Peggy's insecure, high opinion attitude, whatever the Hell Bobby is, dumb as dirt Lou Anne and Hank's by the books, oversight attitude grate on my nerves. Same for Married with Children, sans Al and his circle of friends (Jefferson, Griff, Bob Rooney, etc.). Yeah, it's weird loving the shows but hating the center points