I don't know if there will be a sequel to this game. I wouldn't mind either way, but here are my thoughts on how a sequel to this game could cover so many different topics and subject material that is rarely covered in video games.
1. Very strong female lead, playable character.
TLOU wasn't the first game to let you play as a female, but I can't think of many games (other than RPGS like skyrim, mass effect, etc.) where the story continues with the same female protagonist. Beyond Good and Evil, Heavenly Sword, the Alice games, Metroid, Tomb Raider, are the only series off the top of my head that have linear-stories with a female lead. Beyond good and Evil and heavly sword had the most potential to build a series with a female protagonist, but sequels have not reached the light of day. Tomb raider has been the most successful at creating a strong female lead across multiple games, but Laura's reputation came a lot off of her looks in the early days. It was only with the recent reboot where character development started to really take place. All other games usually don't have enough character development to care about the story behind the character, and merely feed off the fact that players have been with the female character for so long (metroid for example).
If TLOU 2 made Ellie the lead, it would be huge because the character would become even more developed than she already is, possibly leading to one of the most memorable characters in gaming (if she's not already for some people)...and she would be female. There is so much potential to make Ellie into the lead for the entire game, unlike the 25% she is in in TLOU, and it would be awesome to flesh out an already strong female character even more.
2. Female enemies/female-female battles.
Again, TLOU wouldn't be the first game where you could kill females. However, can you imagine if you could play as Ellie, and she has to kill other female survivors? It'd be such a different feeling that is almost entirely absent in gaming. Also, there are a lot of subjects that can be addressed because of this dynamic. For anyone who has seen The Book of Eli, the scene where Mila Kunis (forget the name of her character) tries to help the stranded lady, but it ends up being an ambush for forceful-intimacy. There is potential TLOU 2 could cover situations like that, but we could play as Ellie to get ourselves out of it. She wouldn't need a hero, as she'd be the hero.
Also, there could be situations where Ellie is decieved by other female characters. Women tend to manipulate each other and play "mind games" against one another as my mom always used to put it. Men usually just beat each other up. It'd be interesting to see Ellie get deceived by a female character after a lot of trust is built between them, just because the female/female dynamic would have a totally different feeling than how it was with David/Ellie. I mean, imagine if David had a wife, and instead of David luring Ellie into all those nasty situations, it was his wife? It'd be messed up, especially because you'd think one female would have more respect for another.
It has not been explicitly stated if Ellie is lesbian, straight, or bi. People can make all the assumptions they want based off of that one scene in Left Behind, but the fact of the matter is, Ellie has never stated her attractions and the creators have never confirmed them. TLOU 2 could totally dive into this head-first. Maybe Ellie meets a boy, but struggles with connecting with him. Throw in another strong female to complicate things for her. In any case, TLOU 2 has the potential to make a character struggle with these interal feelings, and the TLOU sequel could ultimately answer the question for us after fleshing out these feelings more. It'd be very interesting, no doubt.
4. Female coming-of-age.
This is kinda just taking everything above and throwing it into one, but TLOU 2 could really be a story about Ellie going from a strong girl to a strong woman, and addressing all of what that covers (don't ask me because I'm a guy). This entails the obvious aspects of the female body preparing for procreation, but (just like guys notice the changes in their voice and...such), it'd be interesting to see how Ellie would take to her body maturing. At the very least, it'd be nice for a game to cover this in a very respectful way. Also, it'd be interesting to have the game address her thoughts towards kids, her ability to have them, and her thoughts towards being a mother. I think this would be a very cool character topic, especially given the circumstances of the world.
Those are just the huge topics that I've been throwing around in my head when thinking about TLOU2 posibilities. The more I think about it, the more I really would want a sequel. But I'd really want it to focus on Ellie. Actually, it'd be an awesome opener if Joel was killed somehow. It'd be just as emotional as the beginning of the first game. Can you imagine how Ellie would handle Joel's death? Imagine now if he died without ever admitting he lied to her (regardless of if she assumed or not). That would cement the first game perfectly and make a great prologue for the second. Joel dies after his lie, and can never admit it or ask for forgiveness. The tradegic hero.
Wow, gosh, now I'm just hyping myself for no reason.
Quite the pro-female suggestion for TLOU2, but you make a lot of solid points.
I always thought it'd be best for Joel to pass down the torch to Ellie after having beaten the game. No offense to Troy Baker, but Joel's character is sorta been-there-done that. - Not literally. The only times in games there are female leads is when the developers are trying to appeal to pervy men to market their game or it's an RPG like skyrim or mass effect.
Ellie would make for a good main character, even without a companion. Or possibly a dog named callus, but after COD ghosts everyone is kinda sour towards dog companions. I'd be interested to see how maturity affects her in that universe, and whether or not she is merely sculpted into Joel's equivelant or a good-intentioned paragon.
With the female coming of age idea, I don't think the media would handle it well. It's a very... difficult subject to be portrayed in gaming. Would we have to craft tampons in the heat of battle or something? I don't think it's really necessary.
The only problem with this is the fact that reviewers are very sensitive about the inclusion of women in games. A reviewer by the name of Carolyn Petite (I think that's her name) even complained that The Last of Us was sexist, utilising female characters to merely advance the plot for Joel (which is a load of baloney but what are ye gonna do ). So unless the female character is completely non-sexualised and kills both men and women, the media won't be happy.
I been looking at concept art for tlou2 where it shows there is no joel but just an older ellie playing guitar. (like joel wanted to teach her). i think this means that joel is dead.. due to the fact that joel would be like 57 years old in the first game. if you havent seen the picture here it is.