Interesting story I would love to walk through Germany with Drake or even Holland (My country) It would also be cool if they would give us some flashbacks like they did with young nate. But then with Harry Flynn and Cutter. I would love to know more about these characters since they are both funny and awesome in their own ways.
One problem. Uncharted has to remain canon and not repeat itself. Lazarevic is dead and the whole "Nazi" aspect was taken with it. We'll need some fresh ideas, like that Gog Magog one from way back.